Genetic, cellular and developmental biology research program
These faculty members use microbial, invertebrate, vertebrate, and plant model systems (including the most genetically tractable model organisms: Drosophila, zebra fish, Arabidopsis, and maize) to genetically dissect the regulation of growth and development. Their research interests include chromosome structure, gene regulation, repair of damaged DNA, interactions between mitochondrial and nuclear genomes, intracellular trafficking and the cytoskeletal architecture, and intercellular and intracellular signaling mechanisms that regulate early development, later growth, and aging in a variety of cells, tissues and organs.
Faculty
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Making cancer chemotherapy more effective |
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Regulatory gene balance, dosage compensation, gene silencing, centromere activity and artificial chromosomes |
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Mechanisms regulating neuronal development and physiology |
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Mechanisms of recombination in soil bacteria |
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Epigenetic influences on plant gene expression; plant genetics and molecular biology |
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Signaling and activity of skeletal muscle satellite cells |
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Plasma membrane structure and function in skeletal muscle development; intercellular signaling in the regulation of myoblast fusion |
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Molecular and cellular analysis of axon-glial interactions; neurodegenerative and demyelinating diseases. |
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Bacterial pathogenesis and genome evolution |
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Stem cell biology and therapies for neurodegenerative diseases and brain tumors |
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Environmental and homeostatic regulation of growth and development |
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Adult neurogenesis |
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Plant molecular genetics; mitochondrial genetics |
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Intracellular protein trafficking and sorting |
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Mucosal cell biology |
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How do individual neurons balance plasticity and stability in the nervous system? |
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Mechanisms and control of transcription of eukaryotic genes |
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Meiotic silencing by unpaired DNA - a new RNAi phenomenon? |
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Molecular imaging of cancer through phage display |
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Autophagy - when a cell has to eat itself! |
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Developing methods for generating conditional mutations and studying cytokinesis during Drosophila gametogenesis |
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Molecular mechanisms regulating cellular signaling in plants |
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Molecular and genetic analysis of transcriptional regulators during neural development |
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Structure and dynamics of biological membranes and membrane components using neutron diffraction |
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Mechanisms of learning and memory in Drosophila |
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University of Missouri-Columbia
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Sublime Slime: Steve and Hannah Alexander apply proteomics to study the slime mold Dictyostelium discoideum in cancer research
Jim Birchler and colleagues attach genes to minichromosomes in maize
Maize Mapping Project associate project director Karen Cone and project members unveil new maize genome map
Mark Kirk and colleagues: stem cell therapy shows promise for neurodegenerative disease
George Smith receives 2007 Promega Biotechnology Research Award
Troy Zars works to localize memory in Drosophila